The science behind Pearl

Our fertility kits come with testing strips of so called “lateral flow immunoassays” (LFIAs), which detect different hormones in urine. This works, because they measure hormonal levels by “binding” the hormone to specific biomolecules.

These biomolecules are labelled with metallic nanoparticles that then appear colorful and can be seen as “visual reporters” of the test results. So once the strips have been subjected to urine, the colourful lines that appear detect the extent and concentration of the hormone you are currently testing.

Since it can be quite challenging and not possible to make an accurate and precise interpretation of these strips with the naked eye, most laboratories have special equipment, which can decode the hormonal concentration with an accuracy of 99.9%.

The Pearl software

The heart of our software is a propietary algorithm. It detects a pattern of three vital hormones in your body: FSH (Follicle-stimulating hormone) your LH (Luteinizing hormone) and your PdG (Progesterone). On basis of that hormon pattern, the software accurately predicts your fertile window.

Costly laboratory tests may be very accurate but hard to perform at home. That is why pearl leverages the accuracy of the hormonal test strips to detect hormone. This is possibel through the help of an intelligent algorithms that predict events happening in the cycle well in advance.

Your hormones, your ovulation, and the fertile window

On basis of your hormonal records…

…our algorithm calculates your exact fertile window.

After ovulation, your egg is only viable for 12-24 hours. However, your partner's sperm can survive inside your body up to 2 to 6 days after coitus.

These facts together influence your fertile window, that is why it starts a couple of days before ovulation and ends approximately two days after.

Furthermore, the fertile window covers the 6-8 days in each cycle, when you have the highest chances to conceive. Still, the chances to conceive during each of these fertile days may vary.

[1] Ecochard, R., et al. "Use of urinary pregnanediol 3-glucuronide to confirm ovulation." Steroids 78.10 (2013): 1035-1040. Baird, Donna Day, et al. "Using the ratio of urinary oestrogen and progesterone metabolites to estimate day of ovulation." Statistics in medicine 10.2 (1991): 255-266.

[2] Rubenstein, B. B., Strauss, H., Lazarus, M. L., & Hankin, H. (1951). Sperm survival in women, motile sperm in the fundus and tubes of surgical cases. Obstetrical & Gynecological Survey, 6(5), 757.

[3] Stanford, Joseph B., and David B. Dunson. "Effects of sexual intercourse patterns in time to pregnancy studies." American Journal of Epidemiology 165.9 (2007): 1088-1095.